mRNA vaccines produce an unusually high fraction of IgG4 against spike. Some have falsely claimed this indicates tolerance developing against SARS-CoV-2. The truth of IgG4 is more complex.
IgG4, COVID, and mRNA vaccines: Not so Tolerant
IgG4, COVID, and mRNA vaccines: Not so…
IgG4, COVID, and mRNA vaccines: Not so Tolerant
mRNA vaccines produce an unusually high fraction of IgG4 against spike. Some have falsely claimed this indicates tolerance developing against SARS-CoV-2. The truth of IgG4 is more complex.