3 Comments
Sep 4Liked by Edward Nirenberg

Whoa, thank you! This was one helluva deep dive, and I really appreciate all the time and effort you put into pulling all of this together.

The Novavax Fandom is quite vocal, and the folks insisting on sinister motives for it not being more available are exhausting.

I did get a Novavax XBB vaccine in January mostly because I wanted to check it out. I had previously taken every Moderna spork available, plus I had covid in August 2023, so I figured I was still decently protected against severe disease even if the Novavax wound up being a total dud. (I'm otherwise healthy, I still mask indoors, I'm a C-R box nerd, etc.)

I admit it was a pleasant surprise not having the usual post-mRNA blecchies, but given everything else you discussed (especially them citing horribly problematic supplement shills -- WTAF??) certainly gives me a lot of pause.

Thanks again-- I really enjoy reading your writing.

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Sep 5Liked by Edward Nirenberg

I agree with Jill! This is my second favorite deep dive so far that you've done, second to the IgG4 and mRNA article.

No pressure, just thanks for these so far :)

Going to read more slowly later.

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Sep 7Liked by Edward Nirenberg

WHAT SHE SAID! That was one helluva read, and I went and slammed the subscribe button pretty hard and fast. I particularly appreciate FINALLY getting a bit of an explanation of how exactly the furin cleavage site worked, I've been looking for that for about four years. (This missing piece for me was that there was a fusion peptide held between S1 and S2.)

I admit to being a little bit of a Novavax stan (tho less so now) although I always always disclosed to people that my affection for it was not entirely logical. (Partly I have a very deep-seated belief in Diversity is a Good Thing, and want there to be alternatives to the mRNAs.) I myself rotate through All The Vaxes (again, because diversity) : AZ first (in part because I could get it fastest), then Moderna, Pfizer, and Novavax. Is heterologous the way to go? I don't know, but I'm not convinced that anybody knows. ;-)

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